Opiant Pharmaceuticals, Inc. Announces Results of Positron Emission Tomography (PET) Study of Naloxone Nasal Spray
The purpose of the study was to determine the extent and time course of brain mu opioid receptor occupancy following the administration of two doses (four milligrams and two milligrams) in healthy volunteers. Mu opioid receptors mediate the actions of both prescription opioids and illicit drugs such as heroin, and high occupancy of these receptors by opioids is responsible for the clinical symptoms of overdose such as respiratory depression that can often be fatal.
“We are highly encouraged by the results of this study, which support the potential advantages of the 4 milligram dose of nasal naloxone,” said Dr.
“This study attests to Opiant’s ongoing commitment to innovation in the addiction and opioid overdose space, and these data may have relevance to our broader pipeline,” Dr. Crystal concluded.
This study was the first use of PET imaging to assess nasal naloxone on opioid receptor dynamics. The 4 milligram dose resulted in a larger degree of receptor occupancy in the brain than the 2 milligram dose, and receptor occupancy was also achieved more rapidly with the 4 milligram dose. Nasal naloxone was safe and well tolerated at both dose levels.
Opiant participated in the funding of this study with an unrestricted academic grant. The study results will soon be independently published in a scientific journal.
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