News Release Details
Opiant Pharmaceuticals Announces Notice of Allowance for U.S. Patent with Claims Covering OPNT004 for the Treatment of Cannabinoid Hyperemesis Syndrome
"This patent allowance is welcome news, and a testament to our commitment of bringing innovative science to the treatment of addictions and drug overdose,” said
The USPTO issued a Notice of Allowance for
OPNT004 (drinabant) is a high affinity, CB-1 antagonist for the treatment of excessive cannabinoid use. Cannabinoids are compounds found in the cannabis plant or made synthetically, that bind to cannabinoid receptors found in the central nervous system, gastrointestinal tract and immune system. With support from the National Center for Advancing Translational Sciences (NCATS), Opiant is developing a formulation for the parenteral administration of OPNT004 for the potential treatment of cannabinoid-related toxicities, which include cannabinoid hyperemesis syndrome (CHS) and acute cannabinoid overdose (ACO), a condition when excessive tetrahydrocannabinol (THC) can cause anxiety, paranoia, visual and auditory hallucinations, and nausea. There are currently no FDA approved therapeutics for either CHS or ACO. Opiant expects to initiate Phase I studies for OPNT004 in 2023. Opiant is developing drinabant under a license from
About cannabis hyperemesis syndrome (CHS)
Cannabinoid hyperemesis syndrome (CHS) is a syndrome of cyclic vomiting associated with cannabis use. While the onset of symptoms is sudden, CHS occurs in people who use cannabis regularly, and has been linked to long term cannabis use. People with CHS experience reoccurring episodes of nausea, vomiting, dehydration, and abdominal pain, which can result in frequent visits to the emergency department. The condition is generally unresponsive to traditional anti-emetics, which are medications used to prevent or treat nausea and vomiting. However, CHS can lead to health complications if left untreated. Only a small portion of people who regularly use cannabis develop CHS. Because CHS was first described in the medical literature less than 20 years ago, many people may have it and either not report it or are misdiagnosed. One analysis found that CHS was responsible for up to 6% of patients who visited the emergency room for vomiting.2
About Opiant Pharmaceuticals, Inc.
This press release contains forward-looking statements. These statements relate to future events or our future financial performance and involve known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance, or achievements to be materially different from any future results, levels of activity, performance or achievements expressed, implied or inferred by these forward-looking statements, and among other things, the completion of the development of OPNT004. In some cases, you can identify forward-looking statements by terminology such as "may," "will," "should," "could," "would," "expects," "plans," "intends," "anticipates," "believes," "estimates," "predicts," "projects," "potential," or "continue" or the negative of such terms and other comparable terminology. These statements are only predictions based on our current expectations and projections about future events. You should not place undue reliance on these statements. Actual events or results may differ materially. In evaluating these statements, you should specifically consider various factors. Additional factors that could materially affect actual results can be found in our Form 10-K for the year ended December 31, 2021, and our Form 10-Q for the quarter ended
For Media and Investor Inquiries:
- The United Nations World Drug Report 2022; Press Release: https://www.unodc.org/unodc/en/frontpage/2022/June/unodc-world-drug-report-2022-highlights-trends-on-cannabis-post-legalization--environmental-impacts-of-illicit-drugs--and-drug-use-among-women-and-youth.html
- Simonetto DA, Oxentenko AS, Herman ML, Szostek JH. Cannabinoid hyperemesis: a case series of 98 patients.
Mayo Clin Proc. 2012 Feb;87(2):114-9. doi: 10.1016/j.mayocp.2011.10.005. PMID: 22305024; PMCID: PMC3538402.
Source: Opiant Pharmaceuticals