Title of each class of securities to which transaction applies:
Aggregate number of securities to which transaction applies:
Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is calculated and state how it was determined):
Proposed maximum aggregate value of transaction:
Total fee paid:
Amount Previously Paid:
Form, Schedule or Registration Statement No.:
This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting.
If you want to receive a paper or e-mail copy of the proxy materials you must request one. There is no charge to you for requesting a copy. To facilitate timely delivery please make the request as instructed below before 06/01/19.
Please visit http://www.astproxyportal.com/ast/21992/, where the following materials are available for view:
* Notice of Annual Meeting of Stockholders
* Proxy Statement
* Form of Electronic Proxy Card
* Annual Report on Form 10-K
TO REQUEST MATERIAL:
TELEPHONE: 888-Proxy-NA (888-776-9962) 718-921-8562 (for international callers)
ONLINE: To access your online proxy card, please visit www.voteproxy.com and follow the on-screen instructions or scan the QR code with your smartphone. You may enter your voting instructions at www.voteproxy.com up until 11:59 PM Eastern Time the day before the cut-off or meeting date.
IN PERSON: You may vote your shares in person by attending the Annual Meeting.
TELEPHONE: To vote by telephone, please visit www.voteproxy.com to view the materials and to obtain the toll free number to call.
MAIL: You may request a card by following the instructions above.
1.Election of Directors:
2. Ratification of Independent Registered Public Accounting Firm.
3. Advisory Approval of our Executive Compensation
Dr Roger Crystal
4. Advisory vote to determine frequency of the vote on executive compensation
THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" THE LISTED NOMINEES, "FOR" PROPOSALS 2 AND 3, AND EVERY THREE YEARS FOR PROPOSAL 4
Please note that you cannot use this notice to vote by mail.